Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice
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چکیده
منابع مشابه
Regenerative Effect of Bone Marrow-derived Mesenchymal Stem Cells in Thioacetamide-induced Liver Fibrosis of Rats
The present study determined the regenerative effect of bone marrow-derived stem cells (BMSCs) on thioacetamide (TA)-induced liver fibrosis in rats. A total of 30 male Wistar rats were randomly divided into sham control and treatment groups. The rats of the sham control group were subdivided into three groups and sampled on the 14th, 18th, and 20th weeks after fibrosis induction. The rats of th...
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The purpose of this study is to investigate the effect of Ginkgo biloba leaves extract on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were divided into four groups. The mice of the first group were served as control. The experimental animals of the second group were given 150 mg/kg body weight of TAA by intraperitoneal injection, twice w...
متن کاملhe Effects of Rosmarinic Acid on the Liver Fibrosis Induced by Non-alco-holic Steatohepatitis in Male Mice
Background and Objectives: Non-Alcoholic Steatohepatitis (NASH) is a serious and increasing liver dis-ease, which develops into cirrhosis, fibrosis, and hepatocellular carcinoma. Rosmarinic Acid (RA) is a powerful antioxidant and anti-inflammatory compound. Therefore, this study aimed to assess the role of RA on a mouse model of NASH-induced liver fibrosis. Methods: In this research, C57/BL6 mi...
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AIMS Cirrhotic patients commonly have a liver zinc deficiency, which may aggravate liver fibrosis due to the lack of antioxidative effects of zinc. This study examined the ability of polaprezinc, N-(3-aminopropionyl)-l-histidinato zinc, to prevent fibrosis in a rat model of thioacetamide (TAA)-induced hepatic fibrosis. MAIN METHODS Liver cirrhosis was induced by orally administering TAA for 2...
متن کاملDietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats.
Dietary nucleotides reportedly promote functionality and repair in fibrotic liver. Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, which lead to the impairment of the hepatic function. The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleo...
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ژورنال
عنوان ژورنال: Saudi Journal of Biological Sciences
سال: 2018
ISSN: 1319-562X
DOI: 10.1016/j.sjbs.2016.10.007